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Analytical Sciences

Microchemistry and Microscopy Art Diagnostic Laboratory (M2ADL)

Rocco Mazzeo, Silvia Prati

M2ADL operates in the field of Chemistry for Cultural Heritage. In particular, the research work is focused on the development of new analytical methods and procedures for the characterisation and spatial location of organic and inorganic compounds. To this aim the research works are mainly focused on the setting up of advanced spectroscopic techniques, immunochemical approaches and ad hoc chemiometric methods. Moreover, the characterization of objects of historical/artistic/archaeological interest is aimed at studying processes and causes of alteration, identifying the chemical-physical interaction of materials with the environment and testing new materials and restoration products.

Web site:

 

Metodi Analytical methods for nano and biosciences

Pierluigi Reschiglian, Barbara Roda, Andrea Zattoni

The activity of the research group deals with fundamental and instrumental developments of analytical techniques for nano and microdispersed samples in the field of biology, biomedicine, pharmaceutics, food and materials science.
The laboratory facilities include commercial instrumentation for flow field-flow fractionation (F4), and prototypes of gravitational field-flow fractionation (GrFFF) and miniaturized F4 (HF5) developed by the group. The fractionation techiques are coupled with uncorrelated detection and characterization methods including UV/vis spectrophotometry, photo and chemiluminescence, refractometry, static and dynamic light scattering, and mass spectrometry.
In 2010 the group founded the spinoff company byFlow s.r.l. The mission of the company is the technology transfer and commercialization of the outcomes of the research activity. In 2013 the group founded Stem Cell s.r.l., a spinoff company which is subsidiary of UniBo. The spinoff mission is to develop and commercialize an innovative instrumentation for cells separation.

Web site: http://www.byflow.it

 

Laboratory of Chromatography and Mass Spectrometry

Guido Galletti

The research group optimises innovative analytical methods for the quantitative determination of organic pollutants (volatile and semi-volatile organic compounds) and emerging contaminants (pharmaceuticals and their metabolites, nitrosamines and by-products of drinking water disinfection) in environmental matrices. These methods are based on Gas Chromatography / Mass Spectrometry (GC/MS) coupled with Solid-Phase microextraction (SPME), Purge & Trap and pyrolysis. Analytical instruments for on-site monitoring of environmental contaminants are studied. The group main focus is on the application of membrane-Inlet Mass Spectrometry (MIMS) technique to the quantification of volatile organic compounds in industrial emissions, wastewater and drinking water.

 

Environmental Chemistry and Radioactivity Lab

Laura Tositti

Our research activity is mainly focused on the study of environmental inorganic species (both stable and radioactive) in the atmosphere with focus on the physics and chemistry of atmospheric aerosol/airborne particulate matter. The research includes the extensive use of computational methods for the interpretation of the data, as well as the quantification of particulate matter sources (Source apportionment): Chemical Mass Balance, Cluster Analysis, Principal Component Analysis and Positive Matrix factorization, as well as the cluster analysis of back-trajectories applied to experimental dataset  owned by the group . Beside extensive activity in the field of Environmental forensics for several Court Attorneys (5 national cases treated and others in progress) we have gathered experience in stratospheric aerosol, train emission characterization and UAV (drones) based atmospheric monitoring. Radon Priority Areas are another essential field of study covering several volcanic areas such as the Bolsena and the Euganean Hills districts. Extensive radiotracer work is also carried out for geochronological and geophysical purposes such as sediment and peat bog radiodating and pollutant atmospheric deposition in soil matrices.
Our work is carried out both in the framework of basic research and for consultancy.

Web site: Research Topics

 

Laboratory of Analytical and Bioanalytical Chemistry

Aldo Roda, Massimo Guardigli, Mara Mirasoli, Elisa Michelini, Cristiana Caliceti

The laboratory performs (bio)analytical fundamental and applied research through the development and application of innovative analytical methodologies based on chemical luminescence (bio-, chemi-, electrochemi- and thermochemiluminescence) detection. Immunological, enzymatic and gene probe hybridization assays are developed for detecting and quantifying analytes in complex matrices exploiting different formats, from high-throughput methods to portable systems and biosensors for on-field application. Three dimensional printing technologies are used for rapid prototyping of portable analytical devices. Predictive cell-based assays are used to evaluate safety and biological effects of bioactive compounds contained in food and vegetal matrices. New bioluminescent proteins and cell biosensors for clinical, food, environmental and forensic analysis are also being developed. Ultrasensitive luminescence "imaging" is employed to localize analytes in cells, tissues and cultural heritage and for the noninvasive “in vivo” monitoring of physiopathological processes, such as infections and tumors. The laboratory also comprises a separative techniques section equipped with chromatographic instrumentation (i.e., HPLC/UV-Vis and HPLC/ESI/MS) used for biomedical, environmental and pharmaceutical analyses (e.g., search for new biomarkers, quantification of drugs and metabolites for pharmacokinetics and bioavailability studies, clinical proteomics and metabolomics studies).

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Analytical Methodologies

Dora Melucci, Clinio Locatelli

The group is concerned with the development of new research methodologies in Analitycal Chemistry. It is focused in Voltammetry, Analytical Spectroscopy and Chromatography, with data treated by Chemometrics. The main research themes are: trace analysis (in particular of toxic metals), real matrices, validation and chemometric data treatment. Methods characterized by minimal pre-treatment of the sample are developed and validated, and their applicability is evaluated also in the presence of matrix-effect. The main research fields are: agro-food, environmental, bio-tech, cosmetics, forensics.