vai al contenuto della pagina vai al menu di navigazione

Organic Synthesis

Design and synthesis of peptidomimetics as receptor ligands or enzymatic inhibitors

Alessandra Tolomelli

The group is interested in the synthesis of small polyfunctionalized organic molecules, containing linear and cyclic β-amino acids or nitrogen heterocycles, with the aim to obtain bioactive compounds. In particular, the synthesis of peptidomimetics able to bind to integrin receptors, that are overexpressed on cancer cells (αvβ3 ed α5β1), is carried out in order to discover delivery systems for the tumor homing of cytotoxic drugs, enzymatic inhibitors and diagnostics. In the same field, ligands to α4β1 integrin are also studied since this receptor is involved in chronic inflammatory processes and in inflammations connected to cancer development. Finally, we are interested in the preparation of oxazolidinone antibiotic analogues  (Linezolid, Eperezolid), aiming to find novel molecules active on antibiotic resistant bacterial strains. The biological activity of the synthesized compounds is evaluated in collaboration with research groups having longstanding expertise on the specific topics.

Web site:


Synthesis and Asymmetrical Catalysis

Marco Bandini

The scientific interests of the group range from methodology in asymmetric catalysis to the synthesis of components for opto-electronics and metal-drugs
1) Stereoselective methodologies applied to the synthesis of complex molecular structures. Focus of the research team main deals with the development of innovative metal and metal-free enantioselective catalytic procedures for the realization of structurally elaborated heterocyclic scaffoled. Particular mention to the chemistry of indole ajd relative polycyclic scaffolds with pharmacological properties. In this segment the use of new stereoselective Au(I) mediated protocols has been extensively explored. 2) Transition metal complexes for applications in opto-electronics and metal-drugs.The research line encompasses the synthesis and full characterization of new neutral as well as cationic cyclometallated complexes [i.e. (Ir(III)), Au(I)]. Collaborations with national and international research groups for the device-assembling as well as pharmacological tests are on-going.

Web site:


Green Chemistry Laboratory for Environmental Sciences - Ravenna Campus

Emilio Tagliavini, Paola Galletti

The group carries out research in organic chemistry  in the Green Chemistry field context  aiming at safeguarding  of environment and sustainability. The activities are highly interdisciplinary and projects involve collaboration with other disciplines of chemistry but also with  biology , algology and ecotoxicology groups. The main topics of research are : 1 ) use of renewable resources for the development of new materials , fuels and fine chemicals ; 2 ) development of new methods for the extraction of high value-added compounds from algal and terrestrial  biomass  through the use of alternative solvents ; 3 ) low environmental impact asymmetric catalysis reactions; 4) evaluation of (eco) - toxicity and environmental impact of chemical compounds ; 5 ) determination of the effects of chemical compounds on models of cell membranes through biophysical methods ; 6) study of the organic component of the environmental aerosol and its effects on climate and air quality.

Web site:


Organic synthesis and biocatalysis to get biologically active molecules

Daria Giacomini, Paola Galletti

The focus of the research group is on the design, synthesis, and development of new molecules with defined biological activities by means of chemo-enzymatic methodologies. We currently study the obtainment of new molecules with a beta-lactam central core decorated with specific substituents in such a way that these groups define the biological activities. We obtained new monocyclic beta-lactam compounds with antibacterial activity against resistant bacterial strains such as MRSA, some others as inhibitors of some important proteins such as Human leucocyte elastase, Matrix metallo proteases, thrombin, histone deacetylases HDAC 6 and HDAC8. Recently we reported an important development on new beta-lactams as selective integrin ligands. For what concerns biocatalysis, it is widely recognized that catalysis by enzymes is selective and sustainable by means of the high efficiency, chemo- regio- and stereo-selectivities. We study Lipases, alcohol dehydrogenases (immobilized and engineered), and recently Laccases.


Laboratory of Organic Synthesis

Marco Lombardo, Claudio Trombini

Development of synthetic strategies directed to a platform of objectives spanning from chemical sensors, catalysis and bioactive molecules. i) Design of endoperoxides with antimalarial activity and molecules active against Human Leishmaniasis. A promising approach involves the design of hybrid molecules in which two pharmacophores are covalently bound through a suitable spacer. ii) Design and fine tuning of new catalysts and catalytic processes, exploiting metal catalysis, organocatalysis or carbocatalysis, to achieve high efficiency and selectivity and directed to the construction of multiple stereocenters starting from achiral reagents. iii) In the field of metal ion sensing (Mg++, Zn++), 8-hydroxyquinolines-azacrown hybrid structures able to give rise to fluorescent complexes have been assembled and the corresponding complexes observed in cells using confocal microscopy. Moreover, thermochemiluminescent 1,2-dioxetanes are currently being studied and designed in order to develop high performance reagent-less bioanalytical techniques.